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Monday, July 20, 2020 | History

2 edition of Relation of myocardial structure to cardiac function in a canine cardiomyopathy model found in the catalog.

Relation of myocardial structure to cardiac function in a canine cardiomyopathy model

Gregory L. Burns

Relation of myocardial structure to cardiac function in a canine cardiomyopathy model

by Gregory L. Burns

  • 168 Want to read
  • 33 Currently reading

Published .
Written in English

    Subjects:
  • Veterinary cardiology.,
  • Dogs -- Physiology.,
  • Dogs -- Cardiovascular system.

  • Edition Notes

    Statementby Gregory L. Burns.
    The Physical Object
    Paginationxiii, 131 leaves, bound :
    Number of Pages131
    ID Numbers
    Open LibraryOL16569555M

    It has become clear that myocardial perfusion and cardiac function are not necessarily compromised when the heart enlarges either during normal growth (Chap. 3) or under some conditions of. Metabolic aspects of myocardial disease and a role for L-carnitine in the treatment of childhood cardiomyopathy. Pediatrics. Jun;(6) Bean BL, Varghese PJ. Role of dietary magnesium deficiency in the pressor and arrhythmogenic response to epinephrine in the intact dog. Am Heart J. Jan;(1)

      To assess the relationship between improved regional and global myocardial function in patients with ischemic cardiomyopathy in response to β-blocker therapy or revascularization. Cardiovascular Magnetic Resonance (CMR) was performed in 32 patients with ischemic cardiomyopathy before and 8 ± 2 months after therapy. Patients were assigned clinically to β-blocker . Cardiomyopathy and distal symmetrical polyneuropathy (DSPN), including sensory and autonomic dysfunction, often co-occur in diabetic mellitus (DM) patients. However, the temporal relationship and progression between these two complications has not been investigated. Using a streptozotocin DM animal model that develops insensate neuropathy, our aim was to examine in parallel the .

    abnormality in cardiac structure, function, rhythm, or con-duction. In developed countries, ventricular dysfunction accounts for the majority of cases and results mainly from myocardial infarction (systolic dysfunction), hypertension (diastolic and systolic dysfunction), or in many cases both. Degenerative valve disease, idiopathic cardiomyopathy. Furthermore, in patients with dilated cardiomyopathy (DCM), differences in short-axis and long-axis dilatation result in changes in fiber angles that may further impair LV twist and thus cardiac function. In the present study, it was hypothesized that a change in cardiac shape may indeed lead to a change in the arrangement of myocardial fibers.


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Relation of myocardial structure to cardiac function in a canine cardiomyopathy model by Gregory L. Burns Download PDF EPUB FB2

1. Eur Heart J Cardiovasc Imaging. Apr 1;20(4) doi: /ehjci/jey Relation of regional myocardial structure and function in hypertrophic cardiomyopathy and amyloidois: a combined two-dimensional speckle tracking Cited by: 6.

Introduction. Left ventricular (LV) remodeling in myocardial infarction (MI) involves progressive dilatation of the LV cavity and an increase in LV wall stress, leading to congestive heart failure.1, 2 The ventricular constraint procedure is a non-transplant surgical treatment for heart failure, where the entire epicardial surface is wrapped with a prosthetic material designed as a mesh Cited by: 6.

This is of utmost importance when assessing myocardial structure, perfusion and wall motion. Cardiac planes. All imaging modalities define, orient and display the heart using the long axis of the left ventricle and selected planes oriented at 90° angles relative to the long axis/5(6).

As a primary myocardial disorder, the myocardial dysfunction of dilated cardiomyopathy occurs in the absence of other disorders that can cause dilated myocardium, such as severe occlusive coronary artery disease or conditions that involve pressure or volume overload of the ventricle (eg, hypertension, valvular heart disease).In some patients, dilated cardiomyopathy is believed to start with.

In this type of cardiotoxicity, there is a period during which the patient is asymptomatic (normal cardiac function). After that, chronic dilated and/or restrictive cardiomyopathy can be manifested with subsequent development of congestive heart failure.

In this case, mortality rate is more than 50% [3, 12, 13, 15].Cited by: 2. Dilated cardiomyopathy (DCM), characterized by chamber dilatation and myocardial systolic and diastolic dysfunction, is one of the most common heart diseases in dogs. The clinical diagnosis is base.

The cardiac ECM is an active system that responds to the stresses to which it is exposed and in the normal heart is adapted to facilitate efficient mechanical function.

There are marked differences in the short- and medium-term changes in ventricular geometry and cardiac ECM that occur as a result of volume overload, hypertension, and ischemic.

Radiation-induced cardiomyopathy can be directly related to the exposition to radiation or can turn up consequent to coronary disease and/or postactinic valvulopathy. Even if the relation between the dose and the type of cardiac damage is unknown, it seems that doses of about 35 Gy determine myocardial impairment.

Nevertheless, the real. Myocardial deficiency, however, may require a higher dosage of mg/kg, by mouth, to maximize the chances that carnitine supplementation will improve cardiac function, based on a.

Cardiomyopathies are heterogeneous heart muscle disorders with a wide range of aetiologies and clinical manifestations. They are often defined by their causes (i.e. hypertension, prior myocardial infarction, valvular heart disease), although current major society definitions describe cardiomyopathy as the presence of abnormal myocardial structure and/or function in the absence.

DCM is characterized by decreased cardiac function and enlargement of the heart, and represents the most common form of non-ischemic cardiomyopathy.

About 30% of DCM cases are caused by inherited mutations in a variety of proteins that are found in the cytoskeleton, sarcomere and nuclear envelope (Hershberger et al., ). mathematical models provide a suitable platform to test hypotheses on the relation between local mechanical stimuli and responses to cardiac structure and geometry, such as changes in mass (18, 22), shape (), and internal myofiber arrangement (2, 10, 17, 26).Model-based prediction of a realistic myocardial structure and geometry could substantiate the role of hypothesized stimuli and.

Howard RJ, Stopps TP, Moe GW, et al. Recovery from heart failure: structural and functional analysis in a canine model. Can J Physiol Pharmacol ; Morgan DE, Tomlinson CW, Qayumi AK, et al.

Evaluation of ventricular contractility indexes in the dog with. The repetitive left-sided coronary artery microembolization model is another method to create myocardial ischemia, and subsequently an ischemic cardiomyopathy phenotype, in canines.

11–14 In this model, dogs were subjected to multiple coronary artery embolic procedures serially performed over a week period. Experimental tachycardia-related cardiomyopathy (TRCM) is a unique model of dilated cardiomyopathy (DCM) and heart failure (HF).

TRCM is associated with marked left ventricular (LV) dilatation, systolic dysfunction, and disruption of the fibrillar collagen network. 1–7 Further, reduced myocyte adhesion to constituents of the basement membrane 4,8 has been reported in TRCM and. Cardiac muscle tissue is one of the three types of muscle tissue in your body.

It plays an important role in making your heart beat. We’ll go over the unique features of cardiac muscle tissue. Two-dimensional speckle tracking echocardiography (STE) is a relatively new method to detect regional myocardial dysfunction. To assess left ventricular (LV) regional myocardial dysfunction using STE in Duchenne muscular dystrophy model dogs (CXMDJ) without overt clinical signs of heart failure.

Six affected dogs, 8 carrier dogs with CXMDJ, and 8 control dogs were used. Cardiac function depends on a large number of parameters, including atrial function, valvular function, and ventricular function.

A large body of science has demonstrated that these parameters are highly interdependent and rather complex. Indeed, myocardial mechanics constitute a whole research field. Abstract. The interrelationship between myocardial hypertrophy and cardiac function is complex and controversial [1–5].

This relationship is often viewed as a dynamic continuum, with hypertrophy developing as an adaptive response to excessive loading conditions but ultimately becoming associated with myocardial dysfunction and, in the intact organism, cardiac failure.

Introduction. The cytoskeleton of myocardial cells is a well organized structure, with a complex array of proteins that maintain the internal organization of cellular organelles and transmit the mechanical forces within the cell to and from the adjacent cells and the extracellular matrix myocyte cytoskeleton is a major determinant of the intrinsic function of the myocyte and it might.

Recently, left ventricular (LV) strain distribution pattern has been assessed in several cardiac disease states. Tachycardia-induced cardiomyopathy (TIC) is an animal model of non-ischemic cardiomyopathy well characterized in terms of global LV dysfunction but with poor understanding of regional variability in LV function.

We hypothesized that TIC induces specific changes in LV strain.Dilated cardiomyopathy (DCM) is the second most common form of acquired cardiac disease in the dog after degenerative mitral valve disease and the most prevalent in large and giant breeds of dogs. Breeds reported as having the highest prevalence of DCM include Dobermanns, boxers, great Danes, Newfoundlands, Irish wolfhounds (IWH) and English.

Myocardial structure and function. (A) Diffusion tensor "fiber" tracking of a canine heart reveals large-scale connectivity of the end-to-end anastomoses of continuously branching myocytes.

With sufficiently high spatial resolution (especially required at the apex and base) the principal eigenvector can be tracked from asterisk (*) to asterisk (*) while tracing out aspects of the base, apex.